This five-day course touches on the basic principles of designing and identifying new drug molecules improving their properties, and monitoring their effect in cellular model systems and in vivo. The course comprises principles of medicinal chemistry, structural biology, structure-based design, in vitro and cell based screening technology, as well as principles of pharmacokinetics and optimisation of drug in vivo properties.
The course also covers aspects of target validation and identification. Finally it explores several state-of-art imaging technologies, aiming to assess the drug distribution and activity as well as to gain a broader view of disease pathology.
The Pharmacokinetics and Drug Therapy course will provide students with the opportunity to learn more about and discuss the following topics:
- Principles of Medicinal Chemistry
- Introduction to Structural Biology and its use in rational drug design
- In vitro screening technology
- In silico screening
- Cell based screening technology
- Principles of pharmacokinetics
- Optimization of inhibitor properties for in vivo use
- Cellular and in vivo imaging technologies